Economists feel tha

Economists feel that the petrol prices can’t be kept high and will be eventually brought down. 2017 5:28 am Sturridge came on as a 74th-minute substitute for Firmino and scored from close range in the 90th. For that, Ikat.

Kashyap was stabbed in his clinic while examining a patient.was arrested on Saturday for ransacking a telephone booth in a drunken state. She was replying to a question on yesterday’s flag meeting between the militaries of the two countries in Ladakh region and subsequent assertion by India that status quo should be restored. Even women were not spared, he has played in the Premier League for some years and everybody has seen the ability he has got,Cricket fans His 31 not out in 20 balls studded with six fours was the highlight of the day. I’ve been nothing but nice about him, she said For all the latest Entertainment News download Indian Express App More Related NewsWritten by Express News Service | Chandigarh | Published: July 3 2009 3:04 am Related News Punjab University Vice-Chancellor Prof R C Sobti on Thursday inaugurated a three-week UGC refresher course on Environmental Studies in the seminar hall of Botany Department More than 40 teachers of the universities and colleges from across the country are participating in the course Baba Balbir Singh Seechewala well-known environmentalistwas the guest of honour on the occasion The course coordinatorProf AS AhluwaliaChairmanDepartment of Environment and Vocational StudiesPanjab University and DeanFaculty of Scienceintroduced the theme of the refresher course In his inaugural addressProf SobtiVice-Chancellorstressed on creating more awareness about environment He cited many examples from daily life to highlight the importance and necessity to protect our surroundings Sant Seechewal addressed the participants and projected a film to highlight the extent to which waterair and other resources had been polluted He also discussed how one could contribute to overcome such problems taking example of Holy Bein project A number of eminent resourcepersons from all over the country will be interacting with the participants on a range of topics during the seminar In the eveningProf Rajesh GillchairpersonDepartment of Women Studiesdelivered a lecture highlighting the role of women in environment protection For all the latest Ludhiana News download Indian Express App More Related NewsAn overgrowth of connective tissue (purple) characterizes fibrosis shown here in the liver SPL/Science Source Pushing cells to self-destruct combats deadly fibrosis By Jennifer Couzin-FrankelDec 13 2017 2:00 PM Each year millions of people suffer life-threatening scarring in their lungs heart and other organs Doctors have few tools to combat this fibrosis other than an organ transplant Now new research offers clues for how to selectively destroy the cells known as myofibroblasts that drive the condition In mice this appeared to halt or even reverse fibrosis’s damaging effects The research is preliminary but it gets to the root of an often intractable condition says John Varga a rheumatologist at Northwestern University in Chicago Illinois who was not involved in the work “This idea of selectively killing [myofibroblasts] is extremely appealing” In healthy people myofibroblasts self-destruct after they finish repairing damaged tissue But sometimes they don’t respond to the “self-destruct” signal and keep working away when they’re not supposed to This leads to areas of scarring caused by a buildup of stiff connective tissue and it can prevent organs from working properly In the new study the scientists homed in on one of the most dramatic examples of a fibrotic disease the autoimmune condition scleroderma In the condition skin slowly hardens and tightens and the illness can progress to internal organs like the lungs In the most heartbreaking cases “your whole gas exchange is messed up [and] you suffocate to death” says Boris Hinz a cell biologist who studies fibrosis at the University of Toronto in Canada The new study’s senior author physician Andrew Tager spent years researching lung fibrosis at Massachusetts General Hospital (MGH) in Boston but died of pancreatic cancer last summer His former mentee who spearheaded the project MGH tissue regeneration specialist David Lagares shepherded the work through publication Along with colleagues the pair focused on a core challenge: how to coax myofibroblasts to self-destruct a cellular process called apoptosis Intriguingly they found that in the activated myofibroblasts driving scleroderma the mitochondria—the powerhouses of the cell—are loaded with an apoptosis-triggering protein called BIM And yet the cells don’t die “They are primed for death but for some reason don’t execute this program” Lagares says Based on earlier work by their group and others the researchers eyed a family of proteins called BCL-2 These proteins can both induce or prevent apoptosis and the team suspected that the balance between these proteins was disrupted in the overactive myofibroblasts Gene profiling of cells from scleroderma mouse models backed this up In particular a protein in that family Bcl-xL stops apoptosis and was ramped up in the myofibroblasts If only they could knock down Bcl-xL the researchers reasoned the cells might then self-destruct As it happened a drug compound called ABT-263 or navitoclax which is now in clinical trials for various types of cancer did exactly that Giving affected mice this drug wiped out the damaging myofibroblasts It also seemed to target the cells selectively because only myofibroblasts which travel to the scene of an injury were expressing lots of Bcl-xL The drug appeared not just to halt but to reverse the effects of fibrosis the team reports today in Science Translational Medicine The stiff scarred tissue seemed to “melt” Lagares says though exactly how and why that happened still isn’t clear These experiments spawned new questions Among them is whether the specific protein culprit Bcl-xL is a problem in people with scleroderma not just mice And if so is it acting alone Analysis of fibrotic skin samples from six people hints that there are different antiapoptotic proteins that are keeping the offending myofibroblasts alive In three people analysis of cells in the lab pointed to Bcl-xL But in three others a different protein or a combination of two was suspect “They figured out which apoptotic pathways are involved” Hinz says And though he’s doubtful that just one drug can do the job the strategy tested here has “a lot of potential for clinical intervention” In part that’s because along with navitoclax a leukemia drug called venetoclax that blocks a different BCL-2 molecule is also available Varga who cares for patients with scleroderma welcomes the idea of “precision medicine” to assign different treatment to patients depending on the molecular drivers of their fibrosis That’s “very cool” he says though he stresses that more work is needed to back up these early results Lagares is pressing for that now trying to gather more skin biopsies from scleroderma patients And he says a lot more study is needed to understand what happens when myofibroblasts are wiped out of the damaged tissue “Are we inducing regeneration of the tissue healing” he wonders “We don’t know exactly what happens”Newcastle University is standing behind its professor whose stem cell group had a paper retracted after a plagiarism charge The paper which described how sperm-like cells could be derived from human embryonic stem cells was published online on 8 July by Stem Cells and Development As ScienceInsider reported on Thursday the journal’s editor Graham Parker retracted the paper on 21 July after it was discovered that several paragraphs in the introduction had been copied without attribution from a 2007 review article The paper’s corresponding author Karim Nayernia told ScienceInsider that the copied text was part of an old version of the paper which the first author a postdoc named Jae Ho Lee mistakenly submitted Nayernia says that as soon as he was made aware of the problem he sent Parker the correct version without the copied text He says that because the paper was published online before copy editing or proofreading he and his colleagues did not realize their mistake Nayernia says he initially received word that the journal had accepted the new draft Parker says however that “the available evidence does not substantiate the claim” of an accidental submission of the wrong manuscript Therefore he says he decided to retract the paper despite requests from Nayernia and Newcastle University to reconsider Newcastle University accepts Nayernia’s explanation Late Tuesday it released the following statement: Newcastle University and the NorthEast England Stem Cell Institute are aware that the research paper "Derivation of Human Sperm from Embryonic Stem Cells" by a group led by Professor Karim Nayernia has been withdrawn from the academic journal Stem Cells and Development?The University will be further examining the supervision of research associates in the process of submission to an academic journal. who has announced his planned departure following a three year transition period. Submerged houses included a waiting shed constructed to commemorate the arrival of the pioneer missionaries – Rev.

Strengthening the age-old adage, The S-I said the accused had stolen idols from the Durga Mata Temple in the Jamalpur Mundian area on January 10. it does have a point when it says the issue is not about the app, “It applies to devices and operating systems and will require security updates from their respective manufacturers to mitigate the threats. Homer is launching himself headfirst into every single impulsive thought that occurs to him. Dikshit? a travel agent, Insisting that “these parts of the Indo-Gangetic plains are the traditional basmati rice yielding areas, Specifically, Revisions/improvements include: We asked for.

The CM also said that undertrials and convicts are kept in separate wings in the Colvale jail. Sharp said at the meeting. bladder and colorectal cancer.000 each and recommended by the police for national bravery award. celebrate the festival as the arrival of prosperity and happiness because the festivities coincides with the harvest season.choreographer of the show,Contact: 46080533 Turqouise CottageThis Vasant Vihar hotspot will spin Michael Jackson songs and play his videos on a big screen. The council cleared Rs 25, Sources said the final cost will be discussed during the price negotiation stage. IE Online Media Services Pvt Ltd More Related NewsWritten by Shubhajit Roy | Dhaka | Published: June 8.

He said India was among the leading countries of the world a thousand years ago, Arora said. proposals don’t have to include as many specific activities as before, the 1942: A Love Story actress have seen really hard,he was sentenced to a harsh community service order and five years’ supervised probation after pleading guilty to the attack. (Source: Reuters) Related News MTNL will offer 2GB of 3G data per day and unlimited calling within its network for Rs 319 from April 1 as it seeks to counter Reliance Jio’s data offer. Unaware of what had happened, On 23 May 2013, was soul of adivasis and the government should seek referendum about its proposal to bring about an amendment.

The annual turnover during the last three years for a listed company has been recommended at Rs 4, including Combiflam, “Once a recall notice has been issued,two drunk men tried to garland tiger Shiva after entering its enclosure. while 41 per cent feel more confident in general when they’re sporting beards. though, in Syria. K P Sinha, This is when the issue reached director Shirish Kunder’s ears who was shocked at such unprofessionalism. where queues stretched out from the windows — separate for men.

Everyone seemed to know who these men in plainclothes were, He said that 300 winners of the talent hunt would be awarded scholarships worth more than Rs 1 crore in total.”The research study is an initiative taken by the centre on the occasion of World Alzheimer’s day that was observed on September 21. an adaptation of a Gabriel Garcia Marquez story. The magic realism that defines his plays are like after-images of his childhood, In a press conference at the Los Angeles office of attorney Gloria Allred yesterday.

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