Adult Stem Cells Continue to Offer Hope

first_img(Visited 14 times, 1 visits today)FacebookTwitterPinterestSave分享0 Advances with adult stem cells continue to promise new cures without violating ethical concerns over embryo research.Bone from skin:  A test of using iPSCs from skin cells to manufacture bone has been successful in rhesus monkeys, Science Daily reports.  Also encouraging is that the risk of developing tumors called teratomas appears less than previously thought from experiments on mice.  Bone progenitor cells were generated from skin cells derived from the same individual.  “Those progenitor cells were then seeded onto ceramic scaffolds that are already in use by reconstructive surgeons attempting to fill in or rebuild bone,” the article explains.  “And, it worked; the monkeys grew new bone.Blood from umbilical cord:  Scientists at Mt. Sinai Medical Center have overcome a limitation with cord blood stem cells: small numbers.  They identified a technique that causes these cells to “generate in greater numbers making them more useful in adult transplantation,” Science Daily says.  With this advance, adults may share in the life-saving treatment used commonly for pediatric patients.  With their ability to regenerate blood, these stem cells could be useful to treat leukemia, lymphoma, and other blood-related disorders.”Poised for greatness:  Dr. Bradley Cairns and a team at the University of Utah Huntsman Cancer Institute are finding that sperm progenitor cells are “poised for greatness.”  He means that these “mundane” cells that await signals to mature into sperm could be trained to become totipotent (fully capable of differentiation into any cell type); after all, that’s what happens after fertilization with an egg.  By learning the methylation signals on the cells that switch on totipotency, the researchers see new avenues for understanding fertilization, cancer and applications for cells that have the “incredible flexibility to mature into skin, heart, gut, or any type of cell.”Nuclear transfer good in new context :  The phrase “somatic cell nuclear transfer” used to wave red flags about the tainted practice of putting nuclei from embryonic cells into body cells (somatic cells), thereby initiating a process of human cloning.  But what if the nuclei come from skin cells that have been reprogrammed into “embryonic-like” induced pluripotent stem cells (iPSC)?  That capability was demonstrated at Hebrew University of Jerusalem recently.  The press release calls this a “Major step toward future therapies for combating life-threatening diseases by cell replacement.”Are embryonic stem cells needed any more?  If nuclear transfer can be achieved with iPSCs, why use embryos?  That’s a question Gretchen Vogel hinted at in Science Magazine when reporting about parallel research:Last week [prior to May 2, 2014] stem cell researchers finally reached a goal that has eluded them through more than a decade of setbacks and scandal. Two teams have independently derived human embryonic stem cells by cloning adult skin cells. The promise of the technique remains tantalizing: replacement tissues for treating diseases from diabetes to Parkinson’s, matched to the patient whose cells gave rise to them. But the practical, ethical, and legal hurdles are as high as ever. The method will also have to prove its worth against a strong competitor: a way to make personalized stem cells that doesn’t involve embryos.Vogel refers to historical episodes: Dolly the sheep, the Hwang scandal (1/22/14), the Mitalipov announcement (6/20/13), and more.  The ethical line she draws seems arbitrary: “Researchers eagerly set out to clone human cells—not to replicate humans, which most scientists strongly oppose, but to generate early human embryos from which stem cells could be harvested.”  This is arbitrary in the sense that it’s only a matter of what point on the timeline to stop progression of embryo to adult.   Ethical concerns also arise in the treatment of women:But spurred by ethical worries about undue pressure on women, many organizations and governments prohibit paying egg donors. That includes the California Institute for Regenerative Medicine, a major funder of stem cell research, which put these cells off-limits for its many grantees.With ethical concerns driving funding laws, why are some labs so willing to continue work on human embryos for somatic cell nuclear transfer (SCNT), otherwise known as “therapeutic cloning”?Legal issues still constrain SCNT. Many governments forbid or otherwise restrict its use with human cells. In the United States, no federal funding can be used for research that harms or destroys a human embryo, so scientists must set up separate lab space that does not use any National Institutes of Health or other federal grant money. Several U.S. states have banned all human SCNT research.Vogel seems at a loss to justify continued research with SCNT.  Indeed, “The political energy needed to overturn those laws might be hard to generate given that there’s now an embryo-free alternative to producing patient-specific stem cells.”  All she can point to is possible flaws in the use of iPSCs.  Those flaws seem to be rapidly disappearing with each new advance like those reported above.  But until all the differences between embryonic and somatic sources are understood, some scientists want to continue their questionable work.Imagine if Vogel had said, “The political energy needed to overturn anti-slavery laws might be hard to generate now that there’s a free-market alternative to getting work done.”  Good grief; if something is unethical, you don’t do it whether or not there is a benefit.  Embryos are not the slaves of the living.  If human life is sacred, you don’t treat it like a commodity (see 5/15/14).last_img read more

Arellano zooms to 2-0 card

first_imgUPLB exempted from SEA Games class suspension San Sebastian similarly downed Jose Rizal University in straight sets, 25-23, 25-22, 25-21, in the second game to barge into the win column.Prado fired 16 points, while Arocha added 15 for Arellano, bringing to fore the skills and smarts they have learned from playing in the previous PVL Open Conference.FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSSEA Games: Philippines picks up 1st win in men’s water poloSPORTSMalditas save PH from shutout“In the Open Conference we faced better players which allowed us to level up our game,” said Prado in Filipino.That level was in full display as Arellano ran plays like a sure-footed veteran squad against the Lady Red Spikers, whose bevy of power hitters just could not get their game going. Trending Articles PLAY LIST 00:50Trending Articles00:50Trending Articles00:50Trending Articles01:37Protesters burn down Iran consulate in Najaf01:47Panelo casts doubts on Robredo’s drug war ‘discoveries’01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games E.T. returns to earth, reunites with grown-up Elliott in new ad  MOST READ WATCH: Streetboys show off slick dance moves in Vhong Navarro’s wedding LATEST STORIES Issa Viray and Chesca Racraquin tried to hammer their way against the formidable defense of Arellano, scoring 12 and 9 points, respectively.The Lady Chiefs, who downed the St. Benilde Lady Blazers in the opener (25-20, 25-22, 25-17), were never in trouble in the match as coach Obet Javier’s squad was on-point throughout.San Beda took a 16-13 lead in the second set but Mary Anne Esguerra and Necole Ebuen triggered a 5-1 binge to put things in order.“They tried to load up on their serves, that’s why they managed to take the lead,” said Prado, the team captain. “But that’s where we held on to our receives even better.”San Beda, which bested Technological Institute of the Philippines (25-13, 25-18, 25-27, 25-13) in its opener, fell to 1-1.ADVERTISEMENT Catriona Gray spends Thanksgiving by preparing meals for people with illnesses Azkals draw with Yemenis, stay on topcenter_img Brace for potentially devastating typhoon approaching PH – NDRRMC Read Next Photo by Tristan Tamayo/INQUIRER.netArellano University imposed its edge in experience to crush San Beda, 25-22, 25-21, 25-18, Wednesday and remain unbeaten in the Premier Volleyball League Collegiate Conference at Filoil Flying V Centre in San Juan.Jovelyn Prado and Regine Arocha led the Lady Chiefs in scoring their second straight victory and at the same time providing a glimpse of what to expect from the reigning NCAA women’s champions.ADVERTISEMENT LOOK: Loisa Andalio, Ronnie Alonte unwind in Amanpulo for 3rd anniversary View comments Don’t miss out on the latest news and information. LOOK: Venues for 2019 SEA Games SEA Games in Calabarzon safe, secure – Solcom chieflast_img read more

10 months agoBayern Munich veteran Robben: Van Dijk should be proud of his development

first_imgAbout the authorPaul VegasShare the loveHave your say Bayern Munich veteran Robben: Van Dijk should be proud of his developmentby Paul Vegas10 months agoSend to a friendShare the loveBayern Munich veteran Arjen Robben says Liverpool defender Virgil van Dijk deserves great praise for his career progress.Van Dijk kicked off his career at FC Groningen and is now regarded among the world’s best centre-halves.Robben says his countryman should be proud for what he’s achieved.”He has made great strides lately, just look where he came from, and I think we should compliment him on his development,” said Robben.”Facing Van Dijk and Liverpool (in the Champions League) could not be more difficult.” last_img

24 days agoSolskjaer convinced Man Utd on the right path: Not as bad as you think!

first_imgSolskjaer convinced Man Utd on the right path: Not as bad as you think!by Freddie Taylor24 days agoSend to a friendShare the loveOle Gunnar Solskjaer remains convinced Manchester United are on the right path. Solskjaer thinks his side have performed well despite not getting positive results. The Red Devils are in tenth with nine points from seven games following the 1-1 draw with Arsenal on Monday.And Solskjaer says his side have been unlucky not to get more points from their performances.”There are many things we look at that gives me loads of confidence,” he said. “You can talk about performance, but results matter. “You can talk about results – I can talk about six out of seven good performances that weren’t as bad you thought.” About the authorFreddie TaylorShare the loveHave your saylast_img read more

3 days agoLiverpool youngster Hoever aiming for big U17 World Cup

first_imgLiverpool youngster Hoever aiming for big U17 World Cupby Freddie Taylor3 days agoSend to a friendShare the loveLiverpool youngster Ki-Jana Hoever is preparing for a big FIFA U17 World Cup.The talented defender will miss several weeks of action for the Reds as he seeks glory with the Netherlands in Brazil.”I’m really looking forward to it,” Hoever told Liverpoolfc.com.”It’s a big experience to go all the way to Brazil and play games over there in decent stadiums. I hope a lot of people will come to watch and we’ll have a crowd.”It’s a big thing in Holland, a lot of people watch it. It’s on one of the biggest television [networks] in Holland, it’s watched and it’s quite big.”Of course, if you win it or make it far, there’s a lot of attention.” About the authorFreddie TaylorShare the loveHave your saylast_img read more

Northern Iowa Played Two Of The Tournaments Most Exciting Games

Northern Iowa Played Two Of The Tournaments Most Exciting Games

Texas A&M’s comeback against Northern Iowa was pretty epic — like, 3,000-to-1 odds against epic. In this video, Neil Paine and Reuben Fischer-Baum talk about how FiveThirtyEight’s in-game win probability model saw the game unfolding and where it ranked according to our excitement index. They then settle last week’s wager about who could predict the most exciting games of the tournament’s first two rounds.Check out FiveThirtyEight’s 2016 March Madness Predictions.

Mens Basketball Ohio State forward Keita BatesDiop named USBWA National Player of

Ohio State redshirt junior forward Keita Bates-Diop (33) passes the ball in the second half in the game against Michigan State on Jan. 7 in Value City Arena. Ohio State won 80-64. Credit: Jack Westerheide | Photo EditorAfter carrying his team to victory against No. 1 Michigan State Sunday, Ohio State redshirt junior forward Keita Bates-Diop was named the Oscar Robertson National Player of the Week, the U.S. Basketball Writers Association announced Tuesday.On Monday, he also was named Big Ten Player of the Week. In two games last week — against Iowa and Michigan State — the 6-foot-7, 235-pound forward averaged 29.5 points and 10 rebounds. He tied a career-high in points with 27 against the Hawkeyes and surpassed that with 32 against the Spartans. He shot 57.9 percent from the field on 22-of-38 shots, including 4-for-10 from beyond the arc. Bates-Diop has been the Buckeyes’ top player this season and has emerged as a strong contender for the Big Ten Player of the Year award. He has averaged 20 points, 8.8 rebounds and 1.4 assists per game this season. He is ranked 10th in the 2018 kenpom.com player of the year standings. read more

Nearly 200 elementary students in Chula Vista receive new bikes

Nearly 200 elementary students in Chula Vista receive new bikes

first_img Posted: December 12, 2018 December 12, 2018 Updated: 8:19 PM 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsCHULA VISTA (KUSI)- Nearly 200 elementary students at Harborside Elementary in Chula Vista got a wonderful surprise today, an early visit from Santa and a new bike!KUSI’s Elizabeth Alvarez has the details. KUSI Newsroom, center_img Categories: Local San Diego News FacebookTwitter Nearly 200 elementary students in Chula Vista receive new bikes KUSI Newsroom last_img read more